Why kratom isn’t the way out of opioid addiction (and may even lead to it)

Here’s why I tell people I care about to steer clear of Kratom:

Kratom binds to the same receptors in the brain as opioids. So, although it does not contain opiates, it works the same way on the brain. More on that (and a link to the research) below.

I admit: I never have tried Kratom.

And I never would, based on what I have read and heard about it from people I interview.

Here’s why.

Any herb can be incredibly dangerous. I say this admittedly being a proponent of medical cannabis.

But even medical cannabis, which is lacking research due to government restrictions, has plenty of research on the books demonstrating its relative safety.

Kratom does not.

Why? Most natural herbal supplements and the like have not undergone any sort of rigorous clinical trial on humans, so we don’t really know what’s good or what’s bad about them, or what’s the proper dose.

I once was assigned a series of “encyclopedia entries,” as I used to call them, by Healthline. My task was to research each herb then write largely positive reviews about how they can benefit your health.

For the first time I ever, I pulled out of the assignment. Indeed, it was the last paid assignment from Healthline I ever took.

I felt like I was being pushed to find the good in these herbs when all I really could find online was warnings about just how dangerous herbs can be because we know so little about them.

I did not feel comfortable with the assignment, particularly as it pertained to Chinese medicine for which there is so little research.

Kratom is a tree in Southeast Asia. There, its medicinal properties have been lauded and celebrated for centuries.

Indeed, just last year a review of existing research published in Human Psychopharmacology concluded, “Legal sanctions appear to have preceded serious scientific investigations into the claimed benefits of ketum (kratom). More objective-controlled trials and experiments on humans need to be conducted to validate self-report claims by kratom users in the community.”

The researcher reported, “Kratom has long been used by rural populations in Southeast Asia as a remedy for common ailments, to fight fatigue from hard manual work, as a drink during social interaction among men, and in village religious functions. Studies based on self-reports suggest that prolonged kratom use does not result in serious health risks or impair social functioning.

“Two recent trends have also emerged: (a) Kratom is reportedly being used to ease withdrawal from opioid dependence in rural settings; whereas (b) in urban areas, adulterated kratom cocktails are being consumed by younger people to induce euphoria.”

Kratom might actually LEAD to opioid addiction

In the context of the opioid epidemic, many people are experimenting with kratom in a well-intentioned effort to get off opioids.

But when it’s being used by someone already prone to addictive behavior, taking too much kratom could spell disaster.

And in fact, kratom may even LEAD to opioid dependence. More on that in a second.

And can I speak addict to addict? Even when we are of the mindset of getting off drugs, let’s be honest. “Well, if one kratom doesn’t do anything for me, I’ll take two. If two doesn’t do anything, I’ll take three.”

And the next thing you know you’re dizzy and throwing up. Maybe your heart is beating really fast.

Maybe somewhere in the mix you threw an opioid down the hatch on top of the kratom because you weren’t feeling relief from the kratom.

DON’T!

Kratom binds to the same receptors in the brain as opioids. So, although it does not contain opiates, it works the same way on the brain. You can read more about how kratom works on the brain in this Scientific American piece.

So, a person trying to get off opioids with kratom likely isn’t going to see much success. In fact, they may end up craving “the real thing” even more.

It’s sort of like giving a recovering alcoholic like myself benzodiazepines (valium, Xanax, Ativan) for anxiety…they work on the brain the same way as alcohol, so it’s just a really bad idea.

You can read about my personal experience with benzodiazepines by clicking here.

Here’s what FDA Commissioner Scott Gottlieb said about Kratom in a statement to the news media in November:

The FDA knows people are using kratom to treat conditions like pain, anxiety and depression, which are serious medical conditions that require proper diagnosis and oversight from a licensed health care provider. We also know that this substance is being actively marketed and distributed for these purposes. Importantly, evidence shows that kratom has similar effects to narcotics like opioids, and carries similar risks of abuse, addiction and in some cases, death. Thus, it’s not surprising that often kratom is taken recreationally by users for its euphoric effects. At a time when we have hit a critical point in the opioid epidemic, the increasing use of kratom as an alternative or adjunct to opioid use is extremely concerning. 

Read more: FDA blasts unproven opioid detox methods

It’s very troubling to the FDA that patients believe they can use kratom to treat opioid withdrawal symptoms. The FDA is devoted to expanding the development and use of medical therapy to assist in the treatment of opioid use disorder. However, an important part of our commitment to this effort means making sure patients have access to treatments that are proven to be safe and effective. There is no reliable evidence to support the use of kratom as a treatment for opioid use disorder. Patients addicted to opioids are using kratom without dependable instructions for use and more importantly, without consultation with a licensed health care provider about the product’s dangers, potential side effects or interactions with other drugs. 

There’s clear data on the increasing harms associated with kratom. Calls to U.S. poison control centers regarding kratom have increased 10-fold from 2010 to 2015, with hundreds of calls made each year. The FDA is aware of reports of 36 deaths associated with the use of kratom-containing products. There have been reports of kratom being laced with other opioids like hydrocodone. The use of kratom is also associated with serious side effects like seizures, liver damage and withdrawal symptoms. 

Given all these considerations, we must ask ourselves whether the use of kratom – for recreation, pain or other reasons – could expand the opioid epidemic. Alternatively, if proponents are right and kratom can be used to help treat opioid addiction, patients deserve to have clear, reliable evidence of these benefits.

 I understand that there’s a lot of interest in the possibility for kratom to be used as a potential therapy for a range of disorders. But the FDA has a science-based obligation that supersedes popular trends and relies on evidence. The FDA has a well-developed process for evaluating botanical drug products where parties seek to make therapeutic claims and is committed to facilitating development of botanical products than can help improve people’s health. We have issued guidance on the proper development of botanical drug products. The agency also has a team of medical reviewers in the FDA’s Center for Drug Evaluation and Research that’s dedicated to the proper development of drug applications for botanicals. To date, no marketer has sought to properly develop a drug that includes kratom.

So, what makes medical cannabis any better?

In states where it’s legal, especially Illinois, it’s regulated.

It’s heavily regulated in Illinois, in fact. No state is stricter. You know what you’re getting, where it came from, and what’s in it.

EVERYTHING is labeled, right down to THC and CBD percentages per harvest. What you’re about to consume has been tested, guaranteed to be all-natural, and even pesticide-free. It has been followed from seed to dispensary sack.

Kratom in its varying online forms is dangerous. There’s no regulation. It’s potentially addictive.

Stay away from it.

Please like my Facebook page by clicking here!

Check out my celebrity interviews

Check out my portfolio of paid addition/recovery content

Check out my portfolio of paid medical cannabis content

Check out my portfolio of paid mental health wellness content

Check out my portfolio of caregiving/aging/dementia content

6 thoughts on “Why kratom isn’t the way out of opioid addiction (and may even lead to it)

  1. It is interesting that you are bashing something you have never even personally tried. So basically, you are just going off of what the FDA, DEA, and pharma companies say. Kratom is not a treatment for anything, it is an aide. It helps support mood, provides a sense of well being, and aids with opiate detox. A tea made from a tree leaf is sure as hell safer than taking the chemicals that are shoved down our throats by big pharma . 3-5 or more million Americans consume this plant and there’s been zero deaths from it alone. Please educate yourself. And the fact that you’re deleting people’s comments and aren’t willing to allow people to express themselves says a lot about you.

    Like

  2. I left a comment on this article on the reporter’s page. I left a quote from an article and the link. The quote was from an internationally recognized Kratom expert. This expert disagrees with Mr. Heitz and my comment was deleted and I was muted on his page. Here is the exact comment I left.

    NIH, NIDA Postdoctoral Fellow, University of Minnesota
    Ph.D., Medicinal Chemistry, University of Georgia College of Pharmacy
    B.S., Pharmacy, Ohio Northern University

    Christopher McCurdy, Ph.D., is a broadly trained medicinal chemist, behavioral pharmacologist and pharmacist whose research focuses on the design, synthesis and development of drugs to treat pain and drug abuse. For over 20 years, much of his research has focused on opioid, Neuropeptide FF and sigma receptor ligand/probe design, synthesis, pharmacological evaluation and development. He has been successful in discovering unique and selective tools for sigma receptors, NPFF receptors and opioid receptors. He is an internationally recognized expert on Kratom (Mitragyna speciosa), that is under investigation for opioid withdrawal syndrome. A significant portion of his career has been dedicated to the development of novel sigma receptor ligands, in collaboration with a variety of interdisciplinary groups, to generate and optimize selective ligands which could serve as critical experimental tools, and more recently, as potential medication development leads to attenuate the effects of cocaine, methamphetamine and pain. Most notably, he has developed a PET/MR imaging diagnostic agent for visualizing the origins of chronic, neuropathic pain by interacting with sigma receptors at the site of nerve damage. First-in-human studies are currently underway in a Phase 0 trial. In addition to his discovery chemistry roles, McCurdy serves as the director of the UF Translational Drug Development Core.

    “Christopher McCurdy, president-elect of the American Association of Pharmaceutical Scientists, believes that kratom has the potential to work for patients and even help solve the opioid crisis.

    “There’s a huge wealth of anecdotal evidence, and some scientific, that there is definite medical potential for this plant. If it’s not in the treatment of mild and moderate pain, it’s definitely in the treatment of potential opioid withdrawal,” said McCurdy, a medicinal chemist at the University of Florida and director of the UF Translational Drug Development Core. He is one of few scientists in the country who’s examined kratom closely.

    He believes that the success of the plant may lie in its two principal alkaloids, mitragynine and 7-hydroxymitragynine. These chemicals can bond to the body’s opioid receptors and act very much like opioids do, providing some pain relief and causing a release of dopamine, but at a much more toned-down level than prescription pills or heroin. Users say there are mild, if any, withdrawal symptoms.

    Kratom, or Mitragyna speciosa, is an everygreen plant native to Southeast Asia.
    Kratom, or Mitragyna speciosa, is an everygreen plant native to Southeast Asia.
    McCurdy pointed out that his studies indicate that 7-hydroxymitragynine may have some addictive qualities, but when looked at in the entire plant, the ratio of that element is so little that the plant has very low abuse potential, one he likened to coffee.

    And unlike opiods, McCurdy said, kratom doesn’t slow breathing. And that’s key. When people overdose on opioids, whether it is a legally prescribed oxycodone or illicit heroin, their body’s respiratory system completely stops.

    “We’ve never seen respiratory depression in the animal studies that we’ve conducted, and we’ve never seen or heard reports of respiratory depression in the human population that’s been using. And this is something that’s really amazing when you start thinking about a potential treatment for opioid addiction or opioid withdrawal.”

    https://www.google.com/amp/s/amp.cnn.com/cnn/2017/10/26/health/opioid-crisis-kratom-potential/index.html

    Like

  3. Thank you for opinion based on never trying something your judging so harshly, but, after 18 years on Paxil, suffering horrible side effects and discovering Kratom as a safe option to alleviate my depression , i haven’t experienced the horrible side effects pharma drugs have caused me. Kratom is not perfect, but neither is Medical Cannabis, which can be even more dangerous, and yes I have a card to, so I’m expressing my opinion based on personal experience, and not on what I read from mainstream media.

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s